Modi ZJ, et al. - In this population-based cohort study, researchers investigated whether young adult–onset end-stage renal disease (ESRD) is correlated with higher cardiovascular (CV) hospitalizations and mortality with different characteristics vs childhood-onset disease. In young adults with incident ESRD, CV disease accounted for ~40% of deaths. Higher risks for CV hospitalization and mortality were related to lack of preemptive transplant vs hemodialysis and peritoneal dialysis. Identified risk factors can contribute to the development of age-appropriate ESRD strategies to improve this population's CV health.