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Risk factors for very preterm delivery out of a level III maternity unit: The EPIPAGE‐2 cohort study

Paediatric and Perinatal Epidemiology May 14, 2021

Desplanches T, Morgan AS, Jones P, et al. - Utilizing a national French population‐based cohort, researchers sought to examine risk factors associated with outborn deliveries and to estimate the proportion that were probably or possibly avoidable. The sample consisted of 2,205 women who delivered between 24 and 30 +6 weeks in 2011. They used multivariable binomial regression to examine risk factors for outborn delivery related to medical complications, antenatal care, sociodemographic characteristics and living far from a level III unit. Gestational age < 26 weeks, inadequate antenatal care, placental abruption, and increased distance to the closest level III unit were all risk factors for outborn delivery. Preterm premature rupture of membranes, gestational age, intrauterine growth restriction, and haemorrhage were all linked to avoidable outborn deliveries, but not distance. The study identified some modifiable risk factors for outborn delivery; however, when regionalised care is heavily reliant on antenatal transfer, as it is in France, only a subset of outborn deliveries may be avoided. Earlier referral of high‐risk women will be required to achieve full access to tertiary care.

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