Perfetti DC, Galina JM, Derman PB, et al. - This study was sought to distinguish the risk factors for lumbar spine reoperation in patients undergoing lumbar total disc replacement (TDR) at short-, mid-, and long-term follow-up. Researchers conducted a multi-center retrospective cohort study utilizing the New York Statewide Planning and Research Cooperative System database. Researchers included a total of 1,368 patients who had undergone a primary lumbar TDR between January 2005 and September 2013. Logistic regression models were applied to compare reoperation and no-reoperation cohorts and were performed on sub-analyses for significant univariate predictors of reoperation. An 8.8% reoperation rate was identified after inpatient lumbar TDR at two-years, 15.8% at five-years, and 19.5% at ten-years. Reoperation rates at teaching centers align with those reported in FDA IDE studies when stratifying by teaching status. According to the findings, diabetes was the only patient factor influencing the reoperation rate. For lumbar degenerative disc disease, there is a growing consensus that lumbar TDR is a durable and appropriate surgical option. In addition, proper indications are crucial to obtaining good outcomes with lumbar TDR.