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Risk factors for recurrent acute kidney injury in a large population-based cohort

American Journal of Kidney Diseases Oct 30, 2018

Liu KD, et al. - In this retrospective cohort study involving 38,659 hospitalized members of Kaiser Permanente Northern California who experienced an episode of acute kidney injury (AKI) from 2006-2013, researchers assessed the incidence of, and predictors for, recurrent AKI. In patients who had a hospitalization complicated by AKI, the occurrence of recurrent AKI was commonly reported. Along with lower estimated glomerular filtration rate, proteinuria, and anemia, the factors that were found to be related to recurrent AKI were older age, black race, and Hispanic ethnicity. In addition, multivariable predictors of recurrent AKI were concomitant conditions, including heart failure, acute coronary syndrome, diabetes, and chronic liver disease. More chances to develop recurrent AKI were attributed to a higher acuity of illness during the initial hospitalization, but there was no independent association between greater AKI severity of the index episode and an increased risk for recurrence. An increased rate of death was also observed in relation to recurrent AKI.

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