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Risk factors for mortality in lung transplant recipients aged ≥65 years: A retrospective cohort study of 5,815 patients in the Scientific Registry of Transplant Recipients

Journal of Heart and Lung Transplantation Nov 18, 2020

Mosher CL, Weber JM, Frankel CW, et al. - Using the Scientific Registry of Transplant Recipients, researchers analyzed 5,815 adult lung transplants recipients aged ≥65 years, to determine post-transplant survival as well as clinical factors related to post-transplant death. The median survival was estimated to be 4.41 years (95% CI: 4.21–4.60 years). The factors that were independently related to increased mortality in the multivariable model were: increasing recipient age strata, creatinine concentration, bilirubin concentration, hospitalization at the time of transplantation, single lung transplant operation, steroid use at the time of transplantation, donor diabetes, and cytomegalovirus mismatch. Of these 8 risk factors, 5 are easily available, which can help optimizing survival after transplantation by informing risk during candidate selection of patients aged ≥ 65 years. Improved survival may be seen in relation to bilateral lung transplantation vs single lung transplantation. These data demonstrate that life-extending benefits can be conferred by lung transplantation in people aged ≥ 65 years, after careful consideration of risk factors.

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