Vajapey SP, Pettit RJ, Li M, et al. - Via performing a comprehensive review, researchers sought to determine risk factors linked with mid-flexion instability after total knee arthroplasty (TKA). Searching PUBMED, EMBASE, Google Scholar, and Cochrane Library, they identified and reviewed 18 articles meeting inclusion criteria. These comprised 5 computational studies, 5 cadaveric studies, and 8 clinical studies. Per observations, mid-flexion instability after TKA is a clinical entity that differs from other established forms of instability. Mid-flexion instability is associated with patient-related, implant-related, and technique-related factors. This review provide inconclusive evidence concerning the effects of joint line elevation and radius-of-curvature of the femoral component on mid-flexion instability while there was evidence supporting a possible bigger role of articular surface conformity and preoperative joint laxity than previously thought. As evidence gained on this topic is derived, in majority, from computational and cadaveric studies, they emphasize the necessity for further clinical studies.