da Silva TP, et al. - In this study, the immune response of tuberculosis (TB)-HIV patients to Mycobacterium tuberculosis (Mtb) antigens was assessed to evaluate the response dynamics to different antigens over time. In addition, an evaluation was performed of the influence of two different doses of efavirenz and the factors associated with immune reconstitution. Findings revealed differences in immune response in accordance to the specificity of the Mtb antigen, which contributed to a better understanding of TB-HIV immunopathogenesis. IFN-γ production elicited by purified protein derivative (PPD) and 38 kDa/CFP-10 antigens seemed to have a greater magnitude compared to ESAT-6 and were associated with different factors. The low response to ESAT-6, even during immune restoration, indicated an inadequacy of this antigen in determining the immune response of immunosuppressed TB-HIV patients.