Clouston SAP, et al. - In this study performed on males from one clinical center that monitors the health of first-responders (N = 6,857), researchers investigated the link between re-experiencing stressful memories of a traumatic event and prostate cancer incidence. All participants were examined using standardized and validated methods to measure the severity of physical exposures and of re-experiencing memories and stress responses at study enrollment. They found the lowest incidence of prostate cancer in responders with no re-experiencing stress and the highest incidence in responders with severe re-experiencing stress. A positive link between re-experiencing a traumatic event and prostate cancer incidence was revealed for the first time in this study. These findings were compatible with recent rodent model evidence showing a direct biological connection between stress pathways and prostate tumorigenesis.