Durrani AF, Zhao PY, Zhou Y, et al. - In this retrospective chart review, researchers determined the rate of endophthalmitis and evaluated risk factors for the development of endophthalmitis following open globe injury (OGI). From January 2000 to July 2017, they analyzed all patients treated for OGI at the University of Michigan. Exclusion criteria included intravitreal injection or intraocular surgery within 30 days of the injury, as well as less than 30 days of follow-up. In total, 586 out of 993 open globe injuries were involved in the study. Time to globe repair, zone I injury, and the need for additional surgery were identified as factors associated with an increased risk of developing endophthalmitis in a multivariate analysis. Endophthalmitis in OGI may be reduced with prompt globe closure and subconjunctival antibiotics. Furthermore, a one-time dose of systemic prophylactic antibiotics, as well as intravitreal antibiotics if intraocular foreign body removal is delayed, was found not to increase the rate of endophthalmitis.