Henkelmann R, Frosch KH, Mende M, et al. - Researchers conducted this retrospective cohort study of patients with OTA/AO 41 B or C tibial plateau fractures (n = 2,106) with the aim to determine the potential controllable risk factors for surgical site infection (SSI). A total of 94 patients developed deep SSIs, indicating the average SSI rate of 4.5%. In univariate regression analysis, several factors were identified to be linked with a significantly higher SSI risk, namely, number of comorbidities [> 6 vs none], diabetes mellitus, high body mass index, OTA/AO fracture type C, compartment syndrome, and open fracture. As per analysis of microbial sensitivity tests, 55.1% of the pathogens were noted to be resistant to perioperative antibiotic prophylaxis. Most of these risk factors cannot be controlled or are subject to other factors that are difficult to control. However, data suggest that the rate of SSI may be influenced by the choice of perioperative antibiotic prophylaxis.