Pih GY, et al. - Based on 11 years of experience at a single tertiary hospital, the researchers intended to identify potential risk factors associated with acute complications, chronic complications and 30-day mortality after percutaneous endoscopic gastrostomy (PEG). Between January 2005 and December 2015, 401 subjects who underwent first PEG insertion at the Asan Medical Center, Seoul, Korea, were eligible for this analysis. It was observed that PEG was a relatively safe and feasible procedure. However, it was linked with a significantly higher early mortality rate in subjects with platelet count < 100,000/μL or C-reactive protein (CRP) ≥ 5 mg/dL, and lower early mortality rate in neurologic disease group (including dementia, Parkinson's disease, neuromuscular disease, and hypoxic brain damage). During and after PEG, acute complications in subjects with underlying malignancy, and chronic complications in subjects aged ≥70 and those with diabetes mellitus should be considered.