Buendía-Roldán I, Fernandez R, Mejía M, et al. - Given that interstitial lung abnormalities (ILA) develop in around 8–10% of persons over 50 years, but uncertainty regarding their risk factors exists, therefore, researchers addressed this topic herein. They compared 80 (9.7%) of 817 persons recruited in their “Lung Aging Program” who showed ILA with 564 persons of the same cohort with normal HRCT, to assess demographic as well as functional disparities, and with 80 persons, randomly opted from the same cohort for determining biomarkers. They assessed MUC5B (rs35705950) variant, telomere length, and serum concentrations of matrix metalloproteinases (MMP)-1, -2, -3, -7, -8, -9, -12, -13, interleukin (IL)-6, surfactant protein (SP)-D, alpha-Klotho and resistin. Significantly raised resistin, IL-6, SP-D, MMP-1, MMP-7, and MMP-13 were detected in participants with ILA. Overall, findings revealed the presence of interstitial lung abnormalities in around 10% of asymptomatic respiratory individuals enrolled in experts’ lung aging program. Elevated serum levels of pro-inflammatory molecules and MMPs were identified to be related to ILA.