Singh KP, et al. - This post hoc exploratory analysis was performed to determine occurrence, severity, and distress of chemotherapy-induced nausea (CIN) and evaluate in terms of differences in demographic and clinical characteristics, symptom severity, stress, and quality of life (QOL) outcomes between oncology patients who did and did not report CIN in the week prior to CTX. CIN was reported in 47.5% of the 1,296 study participants. CIN was associated with less education, having childcare responsibilities, poorer functional status, higher levels of depression, sleep disturbance, evening fatigue, and intrusive thoughts, receipt of CTX on a 14-day CTX cycle, and receipt of an antiemetic regimen that had a serotonin receptor antagonist and steroid. Patients’ QOL was negatively impacted by CIN. In high-risk patients, pre-emptive and ongoing interventions may alleviate CIN occurrence.