Balgobin CA, Zhang X, Lima FV, et al. - Given the increased risk of acute myocardial infarction (AMI) in pregnancy, researchers here investigated the timing and risk factors for AMI in pregnancy and poor outcome. Screening National Inpatient Sample (2003–2015) in pregnancy, labor and delivery, and postpartum yielded 11,297,849 records with 913 instances of AMI (0.008%). AMI occurred in 111 (12.2%) women during labor and delivery, in 338 (37.0%) during pregnancy and most during the postpartum period (464; 50.8%). Following were identified as predictors of AMI: known coronary artery disease, heart failure, prior valve replacement, and atrial fibrillation. Identification of risk factors of traditional atherosclerosis including hyperlipidemia, obesity, tobacco history, substance abuse, and thrombophilia was done. Significant risk factors in predicting AMI are gestational hypertensive disorders. Prior percutaneous coronary intervention and pre‐eclampsia are the identified risk factors linked with major adverse cardiovascular and cerebrovascular events. Overall observations revealed association of AMI with modifiable, nonmodifiable, and obstetric risk factors. These risk factors can result in devastating adverse outcomes and underscore the necessity for risk factor modification and public health resource initiatives toward the goal of reducing AMI in the pregnant population.