Larsen FTBD, et al. - Through observational cohort studies conducted in Denmark, researchers assessed the predefined risk factors and outcome of seizures in community-acquired bacterial meningitis (CABM), a devastating and often fatal condition. All adults (>15 years of age) with CABM in the North Denmark Region from 1998 to 2014 and at Hvidovre and Hillerød hospitals from 2003 to 2014 were enrolled in the derivation cohort (n=358) and all adults (>18 years of age) with CABM treated at all departments of infectious diseases in Denmark from 2015 to 2017 were enrolled in the validation cohort (n=379) were recruited. Pneumococcal etiology and abnormal cranial imaging were the risk factors for seizures at any time in the derivation cohort, while the effect of being age >65 years and immunocompromised was more doubtful. Abnormal cranial imaging and immunocompromise were ascertained as risk factors when seizures occurring post-admission were examined. An association of seizures at any time was seen with enhanced risks of in-hospital mortality and not favorable outcome at discharge. Pneumococcal etiology and abnormal cranial imaging were verified as risk factors for seizures at any time in the validation cohort. Furthermore, only pneumococcal meningitis stayed significant for the post-admission occurrence of seizure. At any time, seizures were also connected to in-hospital mortality and unfavorable outcome. Hence, for seizures in CABM, pneumococcal etiology, immunocompromise, and abnormal cranial imaging were the observed risk factors. Moreover, seizures were greatly associated with mortality and unfavorable outcome.