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Rheumatoid arthritis-associated interstitial lung disease: Clinical characteristics and predictors of mortality

Respiration Oct 16, 2019

Hyldgaard C, et al. - Researchers investigated a well-characterized, population-based cohort to determine the frequency of progressive fibrosing interstitial lung disease (ILD) (PF-ILD) as well as the clinical features of rheumatoid arthritis (RA)-ILD. Patients with RA-ILD diagnosed and observed at the ILD referral centre in Aarhus, Denmark, from 2004 to 2016, were selected. They used Cox regression models to estimate adjusted hazard rate ratios for mortality. The overall study sample consisted of 102 patients with RA-ILD, among these, the presence of PF-ILD was detected in 52%. Participants were observed over a mean duration of 3.8 years and median survival was estimated to be 7.1 years. The follow-up revealed the deaths of 38 patients, and respiratory causes accounted for most deaths. In a multivariate model, diffusion capacity of the lung for carbon monoxide and high titres of IgM rheumatoid factor were identified as the predictors of death. Overall, findings revealed a common occurrence of PF RA-ILD and high associated mortality.
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