Tan X, Sundström J, Lind L, et al. - In Swedish older men, this study was attempted to evaluate if lower (nighttime/daytime ratio of systolic blood pressure (BP) > 0.9 and ≤ 1) and reverse (nighttime/daytime ratio of systolic BP > 1) dipping of systolic BP is correlated with the prospective risk of being diagnosed with any dementia. Researchers applied twenty-four-hour ambulatory BP monitoring to calculate the nocturnal systolic BP dipping status of men at mean age 71 (n=997; 35% on antihypertensive medication) and 77.6 (n=611; 41% on antihypertensive medication). The outcomes of this study imply that in older men, reverse systolic BP dipping may be an independent risk factor for dementia and Alzheimer’s disease. Reverse systolic BP dipping was linked with a greater risk of being diagnosed with any dementia and Alzheimer’s disease, but not vascular dementia, as seen in time-updated Cox regression (ie, time-updated information on covariates and exposure). Reduced dipping of nocturnal systolic BP was not associated with a higher risk of being diagnosed with dementia. Future trials should assess if therapies lowering nocturnal systolic BP below daytime levels, such as bedtime dosing of antihypertensive medication, can meaningfully curb the development of dementia.