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Retrospective analysis of long‐term outcome 10 years after liver transplantation for Wilson disease: Experience over three decades

Transplant International Apr 25, 2020

Ismail MS, Hassan M, Martinez‐Camacho A, et al. - Long‐term outcomes for patients with Wilson disease (WD) after liver transplantation (LT) were evaluated and risk factors of poor survival were sought. Performing retrospective analysis of UNOS/OPTN data, researchers identified 156 pediatric and 515 adult cases of LT for WD between 1987 and 2016. They performed comparison of these cases with 10,442 pediatric and 104,874 adult non‐WD transplant recipients. Significantly higher survival rates, 3, 5, and 10 years after LT, were reported for adult WD patients (87.5%, 85.4%, and 80.5%, respectively) vs non‐WD patients. Per regression analysis, risk factors for decreased survival for adults with WD were older age, female gender and use of life support at the time of transplant, and for poor survival in pediatric recipients with WD were younger age, male gender, obesity and high serum creatinine at the time of transplant. Findings here suggest that both adult and pediatric WD patients achieve excellent outcomes regarding long‐term patient and graft survival after LT.

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