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Retinal microvasculature and optic disc alterations in non-pathological high myopia with optical coherence tomography angiography

Graefe's Archive for Clinical and Experimental Ophthalmology May 13, 2021

Yaprak AC, et al. - Researchers conducted this prospective, cross-sectional study to examine the early characteristics of retinochoroidal and peripapillary perfusion in non-pathological high myopia (HM) without retinopathy and compare them to the age- and sex-matched healthy individuals utilizing optical coherence tomography angiography (OCTA). Participants in the study were 35 patients (35 eyes) in the non-pathological HM group (axial length ≥ 26 mm) and 35 individuals (35 eyes) in the control group. The vessel densities (VDs) of superficial capillary plexus and deep capillary plexus, as well as the whole vessel density and peripapillary VD, were lower in the non-pathological HM group, but the inside disc vessel density value was comparable in both groups. This suggests that the primary cause of VD reduction is more likely related to globe elongation rather than decreased oxygen and nutrients due to posterior pole thinning (retina, sclera, and choroid).

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