Selewski DT, et al. - This study was performed to longitudinally validate the PROMIS measures in pediatric nephrotic syndrome. Authors realized that the PROMIS Mobility, Fatigue, Pain Interference, and Anxiety domains were sensitive to self-reported changes in disease and overall health status over time in children with nephrotic syndrome. The lack of significant anchoring to clinically defined nephrotic syndrome disease active and remission status suggested an opportunity to improve the measurement of health-related quality of life (HRQOL) in children with nephrotic syndrome through the development of a nephrotic syndrome disease-specific HRQOL measure.