Sartini C, Tresoldi M, Scarpellini P, et al. - In order relieve the overload of intensive care units (ICUs) in the pandemic of coronavirus disease 2019 (COVID-19), with a large number of patients requiring respiratory support, researchers examined if noninvasive ventilation (NIV) use in general wards can be an alternative for some patients. The feasibility of NIV in the prone position was investigated in this study; pronation can recruit dorsal lung regions and drain airway secretions, improving gas exchange and survival in acute respiratory distress syndrome (ARDS). Respiratory parameters were investigated in a case series of 15 patients [Mean age: 59 years (6 years); 13 men] with COVID-19 after using this intervention. All patients exhibited a reduction in respiratory rate during and after pronation compared with baseline; an improvement in Spo2 and Pao2:Fio2 was noted in all patients during pronation; an improvement in Spo2 and Pao2:Fio2 after pronation was noted in 12 patients (80%); the same value was observed in 2 (13.3%); and worsened value was noted in 1 (6.7%). Findings support the feasibility of providing NIV in the prone position to patients with COVID-19 and ARDS on the general wards in 1 hospital in Italy. Further study is required to determine if intubation was avoided or delayed.