Guedikian AA, et al. - Researchers aimed at determining the degree to which E₂ hyperresponsiveness to FSH and antimüllerian hormone (AMH) overproduction in normal-weight women with polycystic ovary syndrome (PCOS) correlate with increased antral follicle number (AFN), hyperandrogenism, and/or metabolic dysfunction. Findings revealed that in normal-weight women with PCOS, serum E₂ hyperresponsiveness to recombinant human (rh) FSH represented increased AFN, while elevated serum AMH levels reflected opposing effects of stimulatory reproductive (hyperandrogenism and increased AFN) vs inhibitory metabolic (body fat) factors.