Decker DA, Higgins P, Hayes K, et al. - The present study was performed to evaluate the adequacy of RCI as monotherapy or adjunctive therapy with etanercept (ETN) in an established animal model of collagen-induced arthritis (CIA). Rats (n = 10 per group) were assigned randomly to receive subcutaneous RCI (40, 160, or 400 U/kg twice daily) alone or in combination with ETN (10 mg/kg 3 times daily), ETN alone, or vehicle (on days 13 through 19), after induction of CIA. They evaluated inflammation via changes in paw edema. The data revealed that RCI attenuated CIA-induced joint structural damage in rats, as monotherapy or adjunctive therapy with ETN. These outcomes suggest the clinical effectiveness of RCI as adjunctive therapy for individuals with RA.