Evenson DP, Djira G, Djira G, et al. - A retrospective study was performed to ascertain the associations between age of men with potential male factor infertility and sperm chromatin structure assay measures of sperm DNA fragmentation and high DNA stainable sperm (HDS), and to correlate these data with those obtained from healthy donor men without reproductive issues. Researchers enrolled a sum of 25,445 men attending infertility clinics. At a specific age, the great heterogeneity of both DNA fragmentation index (DFI) and HDS values prevents the automatic translation of age into an index of DNA fragmentation. Nevertheless, it reinforces the idea that both DFI and HDS evaluation can play a role in diagnosing potential male infertility in cases that are not resolved by routine testing and in cases of multiple miscarriages. DFI and HDS data can guide researchers to prognosticate a man’s fertility potential, to recognize corrective therapeutic methods, as well as to evaluate the risk to the offspring’s health.