Tréhout M, et al. – Researchers performed this examination to study the volume of the corpus callosum (CC) and functional lateralization for language as potential biomarkers and their relationships in schizophrenia (SZ) and bipolar disorders (BD). They concluded that SZ patients demonstrated a reduction of the leftward functional lateralization for language, however, no reduction of CC volume was seen, whereas BD patients displayed a decreased volume of the CC related to a lower leftward asymmetry for language. This research identified distinct anomalies in both SZ and BD that might be considered as specific biomarkers of these disorders related to neurodevelopmental models.

Methods

• 20 patients with SZ, 20 patients with BD and 40 healthy controls (HC) were included in this investigation.
• A functional lateralization index (FLI) was computed for every member within the language comprehension network.
• For every member, the volume of the total CC and those of 3 subregions were extracted.
• These variables and their anatomo-functional relationships were explored.

Results

• According to the findings obtained, SZ patients exhibited a decreased leftward lateralization for language, whereas this was not found in BD patients in comparison to HC.
• In the study, it was observed that BD patients demonstrated a diminishment in CC volume related to a lower leftward lateralization for language as compared to SZ patients and HC.