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Relationship of mildly increased albuminuria and coronary artery revascularization outcomes in patients with diabetes

Catheterization and Cardiovascular Interventions Mar 19, 2019

Siddique A, et al. - By analyzing data from 2,176 patients who underwent percutaneous coronary intervention/coronary artery bypass grafting (PCI/CABG) vs medical therapy in the BARI-2D trial, researchers assessed the link between albuminuria and cardiovascular disease outcomes in diabetic patients undergoing treatment for stable coronary artery disease. By baseline spot urine albumin–creatinine ratio (uACR), participants were stratified into normal (uACR < 10 mg/g), mildly (uACR ≥ 10 mg/g < 30 mg/g), moderately (uACR ≥ 30 mg/g < 300 mg/g), and severely increased (uACR ≥300 mg/g) groups. Between these groups, outcomes were compared. In those with type 2 diabetes mellitus and stable coronary artery disease, all-cause mortality was significantly predicted by mildly increased albuminuria. It also significantly predicted cardiovascular events among non-white individuals.

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