Relationship between viral load, infection‐to‐delivery interval and mother‐to‐child transfer of anti‐SARS‐CoV‐2 antibodies
Ultrasound in Obstetrics & Gynecology Apr 11, 2021
Poon LC, Leung BW, Ma T, et al. - Via this prospective case‐series including consecutive pregnant women with laboratory‐confirmed SARS‐CoV‐2 infection, researchers examined the correlation between SARS‐CoV‐2 viral load and infection‐to‐delivery interval with maternal and cord sera anti‐SARS‐CoV‐2 IgG antibody levels in pregnant women with active or recovered SARS‐CoV‐2 infection. Among 20 pregnant women who had delivered their babies by January 31, 2021, 14 had recovered from COVID‐19 and six had active infection. The median GA was 32.7 weeks at clinical manifestation. In recovered pregnant women with COVID‐19, an increase in anti‐SARS‐CoV‐2 IgG concentrations at delivery was observed with viral load during infection and their reduction was observed with infection‐to‐delivery interval. The median transplacental transfer ratio of IgG was 1.3 and reduction in this transfer was observed by high viral load during infection.
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