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Relationship between peripheral neuropathy, diastolic function, and adverse cardiovascular outcome in individuals with type 1 diabetes mellitus without known cardiovascular disease: Results from the thousand & 1 study

Diabetes, Obesity and Metabolism Oct 09, 2020

Hansen GM, Jorgensen PG, Andersen HU, et al. - in patients with type 1 diabetes (T1DM) and no known cardiovascular disease (CVD), this study was conducted to evaluate the relationship between measures of peripheral neuropathy (PN) and impaired left ventricular diastolic function and prognosis. Researchers further evaluated the incremental prognostic value of including measures of PN and diastolic function to the established Steno T1 Risk Engine. The diastolic function and PN were evaluated via echocardiography and quantitative biothesiometry. They evaluated prognostic capability with Harrell’s C‐statistics and it was tested against the Steno T1 Risk Engine. The study population consisted of 946 individuals (51.5% males). It was shown that, in patients with T1DM, PN, and impaired diastolic function are related with a higher risk of CV‐events and all‐cause death. When using the Steno T1 Risk Engine, measures of diastolic function improved prediction of prognosis.

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