Li G, Compston JE, Leslie WD, et al. - Since the role of obesity in fracture risk remains to be uncertain and inconclusive in postmenopausal women, researchers used data from the Global Longitudinal Study of Osteoporosis in Women 5‐year Hamilton cohort to explore the connection between obesity and risk of major osteoporotic fracture (MOF; ie, a clinical fracture of upper arm or shoulder, hip, spine, or wrist) in postmenopausal women, after taking frailty into consideration. Three thousand nine hundred eighty-five women (mean age: 69.4 years) were included for analyses, among which 29% were obese (n = 1,118). Obesity was significantly linked to a reduced risk of MOF in postmenopausal women among those who were not frail after taking frailty into consideration, however, increasing frailty attenuated this protective effect of obesity. The evaluation of frailty status will aid in understanding the complex relationship between obesity and the risk of fracture.