Kim JA, et al. - Researchers examined how the lamina cribrosa (LC) curvature is associated with the microvasculature within the LC in treatment-naïve eyes with normal-tension glaucoma (NTG) and in healthy eyes. They examined the LC curvature quantified as the LC curvature index (LCCI) in forty-one eyes with treatment-naïve NTG and 41 age and sex-matched healthy control eyes via scanning the optic nerve head (ONH) area, using spectral-domain optical coherence tomography (OCT). They performed OCT angiography of the ONH area to ascertain the LC vessel density (LCVD) in the en face images obtained from the layer segmented at the level of the LC. Treatment-naïve NTG eyes but not healthy eyes showed a significant association of a larger LCCI with a smaller LCVD. This suggests that in eyes with NTG, mechanical strain potentially influences the perfusion within the LC.