Ju W, et al. - This study investigated the links between serum selenium concentrations and lipid concentrations and dyslipidemia. Among rural Chinese, a correlation was apparent, between elevated serum selenium levels and increased concentrations of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c) and triglyceride (TG). Furthermore, high serum levels of selenium increased the risk of High-TC and High-LDLC dyslipidemia.

Methods

• Researchers assessed cross-sectional data including serum selenium levels, lipid concentrations and other related indexes of 8198 rural Chinese.
• They measured serum selenium by inductively coupled plasma mass spectrometry, and total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and low density lipoprotein-cholesterol (LDL-c) of serum with kits.

Results

• Data reported that, overall, mean serum selenium was 120μg/l.
• It was demonstrated in multivariate liner regression that selenium concentrations were positively correlated with TC (P<0.001), HDL-c (P<0.001), TG (P<0.001) and LDL-c (P<0.001).
• Researchers observed that compared with the lowest quintile of serum selenium, participants in quintile 3, 4 and 5 had higher risks of High-TC dyslipidemia (P≤0.02) and High-LDLC dyslipidemia (P<0.02) after adjusting for covariates.
• In the stratified analyses, they found that the selenium-dyslipidemia associations were significantly stronger in post-menopausal women (OR: 2.72; 95% CI: 1.97, 4.17) and diabetics (OR: 9.40; 95% CI: 3.02, 29.26).