Chia CW, et al. - Using data from participants in the Baltimore Longitudinal Study of Aging, the researchers tested the hypothesis that regular low-calorie sweetener (LCS) consumption is associated with higher postprandial glucose-dependent insulinotropic polypeptide (GIP) secretion, which has been linked to obesity. Study participants were who had completed a diet diary, had at least one visit during which they underwent an oral glucose tolerance test (OGTT), and had no diabetes. Results of this study suggested that regular consumption of LCSs was linked with greater increases in GIP secretion after food intake, which could potentially lead to weight gain through the lipogenic properties of GIP.