Bisgaard J, Torp-Pedersen C, Rasmussen BS, et al. - Given the common occurrence of cardiopulmonary comorbidity in cases undergoing vascular surgery and the possibility of impaired perfusion and induction of respiratory depression in correlation with providing general anaesthesia (GA), researchers here examined if a better outcome can be achieved with regional anaesthesia (RA), including neuraxial or peripheral nerve blocks. They conducted a nationwide retrospective cohort study including all open inguinal and infra-inguinal arterial surgical reconstructions. GA was provided in 10,509 procedures and RA was used in 6,850 procedures. After propensity score matching, they included 6,267 procedures in each group. Overall findings suggest the possible correlation of RA with a better outcome, compared with GA, after open inguinal and infra-inguinal peripheral vascular surgery. In the clinical context, GA can still be considered safe when RA is not feasible.