Ma H, et al. - Researchers tested the premise that patients with mild cognitive impairment (MCI) have different magnetic resonance imaging (MRI)-derived regional myocardial motion indices compared with healthy controls. Among MCI patients (age 65.5 years ±5.9; range 55–81 years old) and sex-/age-matched healthy volunteers, different MRI-derived regional myocardial strain, strain rate and velocity were found. MCI patients vs healthy controls exhibited a higher global cortical atrophy score, a lower peak radial strain, lower peak diastolic radial strain rate, lower peak diastolic circumferential strain rate, lower peak systolic radial displacement, lower peak diastolic radial velocity, and lower peak diastolic circumferential velocity. The potential of regional myocardial motion indices to become novel quantitative imaging biomarkers for representing the risk of neurodegenerative disorders, such as Alzheimer’s disease, was suggested.