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Reduction in bone loss from 5 to 20 weeks postpartum in adolescents supplemented with calcium plus vitamin D during pregnancy is not sustained at 1 year postpartum: Follow-up study of a randomized controlled trial

The Journal of Nutrition Feb 13, 2021

Diogenes MEL, et al. - Since calcium plus vitamin D supplementation of pregnant Brazilian adolescents with habitually low calcium intake (∼600 mg/d) decreased bone loss during the first 20 wk postpartum, researchers sought to examine maternal bone mass changes during the first year postpartum as a follow-up of the clinical trial. Pregnant adolescents (14–19 y) got calcium (600 mg/d) plus cholecalciferol (200 IU/d) supplementation (n = 30) or placebo (n = 26) from 26 wk of gestation until parturition. Bone area and bone mineral content and BMD at total body, lumbar spine, and hip (total and femoral neck) were evaluated by DXA at 3 time points postpartum (5 wk, 20 wk, and 56 wk). Supplementation of calcium plus vitamin D in adolescent mothers decreases the magnitude of bone loss in the femoral neck from 5 to 20 wk postpartum without influencing bone changes after 1 y postpartum, suggesting that the tested supplement does not have a sustained effect.

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