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Reduced progression of bone erosion in cytomegalovirus seropositive rheumatoid arthritis patients

Arthritis Research & Therapy Jan 24, 2020

Rauwel B, Degboe Y, Nigon D, et al. - Researchers sought to evaluate the association between human cytomegalovirus (HCMV) seropositivity and bone erosion during rheumatoid arthritis (RA). They included a sum of 487 individuals of ESPOIR cohort who fulfilled the 2010 ACR/EULAR criteria for RA. Using Architect cytomegalovirus (CMV) IgG assay, they assessed HCMV serology for these patients. Univariate and multivariate analyses were conducted to investigate the association between HCMV status and bone erosion progression. They examined 273 HCMV seropositive (HCMV+) and 214 HCMV seronegative (HCMV−) RA individuals. The outcomes demonstrate that, independently of other confounding factors, HCMV seropositivity is correlated with a slower progression of bone erosion during RA.
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