Wenners A et al. -Based on the current study, it is recommended that preservation of fertility should be offered to patients of a higher age with low AMH levels or low follicle counts.

Methods
51 premenopausal women with primary breast cancer were enrolled.
All of the patients received anthracycline-based chemotherapy or combinations with taxanes or anthracycline-free chemotherapy.
Changes in LH, FSH, E2, AMH, antral follicle count, and amenorrhea were determined before (V1), and 6, 12 and 24 months after the initiation of chemotherapy (V2-V4).
The additional impact of parity, BMI, and smoking on ovarian reserve was also assessed.

Results
The AFC and AMH level were decreased after chemotherapy and did not return to pre-treatment levels until V4.
A significant correlation was noted in the AFC before and 1 year after chemotherapy.
The AMH levels at V2-V4 were positively correlated with the levels at V1. and the AFC and AMH level were negatively correlated with age.
Continued smoking had a significant detrimental effect on the AFC after 24 months.
The LH and FSH levels increased between V1 and V2 decreased at V3 and V4, but remained greater than pre-chemotherapy values.
Two years after beginning chemotherapy, 31 of 51 patients were amenorrhoic, while 17 resumed menstrual cycles.
Non-smokers were 13 times more likely to resume menstruation than smokers.
Quality of life was significantly lower 6 months after the initiation of chemotherapy.