Fountoulakis N, et al. - In this single-center observational follow-up study, the researchers ascertained if soluble Klotho (sKlotho) predicts estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus (T2DM) with relatively preserved renal function. For the purpose of this investigation, 101 subjects with T2DM and eGFR >45 mL/min [91% on renin angiotensin system (RAS) blockade] followed for a median of 9 years (range, 2 to 13 years). Reduced levels of sKlotho predicted renal function decline independent of traditional risk markers in patients with T2DM with relatively preserved eGFR. Data reported that sKlotho was a biomarker of renal dysfunction and a potential treatment target for renoprotection in T2DM.