Perea J, et al. - In this study involving 52 consecutive patients without hereditary forms of CRC, researchers analyzed 104 paired-Synchronous colorectal cancers (SCRCs) in order to assess the possible clonal origin of a part of SCRC. They characterized as well as defined the genomic profiles based on clonality within the same individual. Classification of the SCRC Monoclonal group (M) (19 cases) into Monosegmental (MM) and Pancolonic (MP) groups as well as of the SCRC Polyclonal group (P) (33 cases) into Monosegmental (PM) and Pancolonic (PP) was done, the first exhibiting preference for left colon. They observed a high rate of mucinous tumors, the lowest mean-number of tumors and associated-polyps, and the worst prognosis in the MM group. A mucin component, the highest mean-number of tumors (4.6) vs the mean-number of polyps (7.7), poor prognosis and sporadic cases were also observed for the PP group. Clonality seemed to be more accurately defined in SCRC, more likely to be polyclonal in origin, by the statistical application employed. Combined with tumor locations, it helped to configure a classification with prognostic and clinical value.