Kim NH, et al. - Researchers investigated the impact of polymorphisms of cytochrome P450 2E1 (CYP2E1; the main enzyme in the metabolism of nitrosamines) and peroxisome proliferator-activated receptor gamma (PPARγ; a transcription factor implicated in adipogenesis and lipid and glucose metabolism) on the link between red meat consumption and colorectal cancer (CRC) in this case–control study. Participants were patients with CRC (n=971) as well as controls (n=658) who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. By CYP2E1 polymorphisms, variations were evident in the link between red meat intake and CRC; individuals with C alleles of CYP2E1 and those with the GG allele had 2.77 (1.23–6.25) and 0.89 (0.51–1.54) as the respective estimated odds ratios (95% confidence intervals) for at least five or more vs less than one time/week of red meat consumption. According to evidence generated in this study, high susceptibility to the development of CRC risk could be seen in East Asians with the variant type of CYP2E1.