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Recurrent wheezing during the first 3 years of life in a birth cohort of moderate-to-late preterm infants

Pediatric Allergy and Immunology Nov 24, 2019

Moreno-Galdó A, Pérez-Yarza EG, Ramilo O, et al. - Researchers performed this prospective, multicenter birth cohort study to define the incidence of recurrent wheezing as well as related risk and protective factors during the first 3 years of life in moderate-late preterm infants. They evaluated the incidence of physician-diagnosed recurrent wheezing among infants born at 32+0 to 35+0 weeks’ gestation who were observed for 3 years. Information on allergen sensitization and pulmonary function were also obtained. This study included 977 preterm infants. Similar rates of recurrent wheezing were observed during year (Y)1 and Y2 but a decline to 13.3% was reported in Y3. A significant reduction from 6.3% in Y1 to 0.75% in Y3 was also reported for related hospitalizations. Findings revealed the link of respiratory symptoms with lung morbidity persisted during the first 3 years of life as well as with abnormal pulmonary function tests in moderate-to-late premature infants. Results highlighted a protective influence of only anti-RSV prophylaxis in the development of recurrent wheezing.
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