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Recovery of hypothalamic‐pituitary‐adrenal axis in pediatric Cushing disease

Clinical Endocrinology Aug 03, 2020

Tatsi C, Neely M, Flippo C, et al. - Since factors influencing the duration of adrenal insufficiency (AI) and its prognostic significance for Cushing disease (CD) recurrence in children have not been extensively studied, researchers used multivariable Cox proportional hazards analysis to ascertain if clinical or biochemical factors contribute to the duration of AI and the association of the recovery process with the risk for recurrence. The sample consisted of patients with pediatric‐onset CD who were followed up for at least 3 months after transsphenoidal surgery (TSS) (n = 130). Overall, 102 patients had regained their adrenal function during follow-up. Data reported that the median time to recovery was 12.7 months. Except for total cortisol excretion, recovery of adrenal function in patients with CD after TSS may not be correlated with most clinical and biochemical factors in the preoperative period, as evidenced by the association with urinary free cortisol . Earlier recovery is associated with an increased risk of recurrence, which has implications for follow-up and counseling of the patients.

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