Sort R, et al. - In this exploratory, observational study, researchers analyzed the post-peripheral nerve block (PNB) pain profile among adults undergoing acute orthopaedic limb surgery, and investigated whether rebound pain could pose a clinical problem. A total of 21 patients aged 20-83 were administered ultrasound-guided popliteal sciatic and saphenous ropivacaine block anaesthesia for acute primary internal fixation of an ankle fracture. They maintained a record of postoperatively measured pain scores while a fixed analgesics regimen and patient controlled morphine were given on-demand. Findings revealed that rebound pain posed a clinical problem, with the potential to outweigh the PNB benefits, especially for younger patients. Patients >60 years old exhibited less pronounced rebound, but moderate pain levels were reached in nearly all. The rebound was accompanied by high morphine consumption rates.