Gil LV, Mazzeffi MA, Cai Y, et al. - Researchers conducted a retrospective, matched case‐control study of surgical patients who received low‐dose ketamine infusions for postoperative pain over 6 years in order to determine factors linked with early discontinuation of low‐dose ketamine infusions due to adverse drug events (ADEs). They included 47 study patients, who required early discontinuation of their infusion due to ADEs, and matched them 1:1 with 47 controls, who did not experience ADEs, for a total of 94 patients. Comparison of the two groups revealed that patients who were opioid naïve, received less preoperative benzodiazepines, and had greater postoperative opioid PCA requirements had more frequent discontinuation of their low‐dose ketamine infusion due to ADEs. In contrast, control patients had higher rates of preoperative opioid use and experienced fewer ADEs despite greater total ketamine doses.