Labuda SM, Huo Y, Kacanek D, et al. - Human immunodeficiency virus (HIV)–exposed uninfected children (HEU) and HIV-unexposed uninfected children (HUU) in the United State were compared regarding the incidence of all-cause hospitalization and infection-related hospitalization in the first 2 years of life. Further, associations of maternal HIV disease–related factors during pregnancy with risk of child hospitalization were evaluated among HEU. Researchers obtained HEU data from individuals enrolled in the Surveillance Monitoring for Antiretroviral Therapy Toxicities Study (SMARTT) cohort who were born during 2006–2017 and  HUU comparison data from the Medicaid Analytic Extract database, restricted to states participating in SMARTT. In total, they analyzed data from 2,404 HEU and 3,605,864 HUU. Per findings, rates of hospitalization and infection-related hospitalization were higher in the first 2 years of life among HEU children vs HUU in the United States; this is in line with studies in other countries. They emphasize undertaking closer monitoring of HEU infants for infection.