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Rate of correction of hypernatremia and health outcomes in critically ill patients

Clinical Journal of the American Society of Nephrology Apr 11, 2019

Chauhan K, et al. - Researchers examined critically ill subjects with hypernatremia (serum sodium level > 155 mmol/L) at admission (n=122) and those that developed hypernatremia during hospitalization (n=327) in order to evaluate the link between hypernatremia correction rates and neurologic outcomes and mortality. Data were derived from the Medical Information Mart for Intensive Care-III. The investigators estimated various ranges of rapid correction rates (> 0.5 mmol/L per hour overall, and > 8, > 10, and > 12 mmol/L per 24 hours). In critically ill adult patients with either admission or hospital-acquired hypernatremia, there was no evidence of a relation between rapid correction of hypernatremia and higher risk for mortality, seizure, alteration of consciousness, and/or cerebral edema.

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