Nadeem S, Tangpricha V, Ziegler TR, et al. - According to findings, 1000 IU of daily vitamin D ₃ is unlikely to attain or maintain a plasma 25(OH)D ≥ 30 ng/mL in children with chronic kidney disease (CKD). A daily dose of vitamin D ₃ 4000 IU was beneficial in reaching or maintaining vitamin D sufficiency in children with CKD stages 3–5.

• The authors performed a phase III, double-blind, randomized trial of two doses of vitamin D ₃ in children ≥ 9 years of age with CKD stages 3–5 or kidney transplant recipients. The sample consisted of 98 patients (49 randomized into each group).

• Eighty patients (81.6%) finished the research and were analyzed.

• In the 1000 IU and 4000 IU treatment groups, baseline plasma 25(OH)D levels were ≥ 30 ng/mL in 12 (35.3%) and 12 (27.3%) patients, respectively.

• Plasma 25(OH)D levels were ≥ 30 ng/mL in 33.3% and 74.4% in the 1000 IU and 4000 IU treatment groups, respectively, at 6 months.

• There was no vitamin D toxicity or hypercalcemia in any of the individuals.