Schick A, et al. - In this prospective, randomized clinical trial, researchers sought the difference in procedural amnesia and adverse respiratory events (AREs) between the target sedation levels of moderate (MS) and deep (DS) procedural sedation. They randomized consenting adult patients planning to undergo DS with propofol to a target sedation level of MS or DS using the American Society of Anesthesiologist's definitions between March 5, 2015 and May 24, 2017. Observations suggest that the intended sedation level was not reliably achieved via targeting MS or DS. However, on targeting MS, a lower rate of total AREs was noted and there were fewer patients having multiple AREs, with no difference in procedural recall. Hence, targeting MS provides satisfactory amnesia with less necessity for supportive airway interventions vs targeting DS, even though it frequently does not result in intended level of sedation.