Andronikou S, et al. - Using whole-body magnetic resonance imaging (WBMRI), researchers examined the distribution patterns and extent of chronic recurrent multifocal osteomyelitis (CRMO). Children with established CRMO diagnoses who had undergone WBMRI had their images reviewed by 3 radiologists using a new pictorial mapping system to determine patterns of lesion load and distribution. Data reported that 37 children (mean 12 years; range 2–18 years) had 317 lesions. In a bilateral symmetric pattern, CRMO mostly affects tibia and distal femur. Findings revealed that CRMO is usually metaphyseal but it is common to have an epiphyseal and physeal disease. There have appeared two main phenotypic patterns: ‘tibio-appendicular multifocal pattern’ and ‘calviculo-spinal pauci-focal’ pattern. Overall, the authors concluded that WBMRI phenotypes are essential because they can have an effect on long-term results.