Helliwell PS, et al. – In this assessment, radiographic outcomes of patients with psoriatic arthritis (PsA) were compared according to the magnitude of the response to the treatment utilizing three new psoriatic composite disease activity measures (the Psoriatic Arthritis Disease Activity Score (PASDAS), the GRAPPA Composite Exercise (GRACE), and the Disease Activity in PsA (DAPSA). Findings suggested that response criteria for disease specific composite measures offered separation between groups in terms of radiographic progression. Thus, these measures could be used as suitable targets for interventional studies, as well as in the clinic.

Methods

• In this study, response criteria at 24 weeks were applied across the whole dataset, irrespective of treatment group.
• With the aid of Sharp van der Heijde method, modified for PsA, radiographic scores at baseline and 24 weeks were evaluated.

Results

• Investigations showed that for each measure, radiographic progression was significantly greater in subjects with a moderate or poor outcome, and absent in those with a good outcome.
• The proportion of subjects without radiographic progression in the good outcome group was: PASDAS, 83%, χ² = 7.9, p = 0.02; GRACE, 80%, χ² = 5.8, p = 0.05; DAPSA, 76% χ² = 3.4, p = 0.19.